McAfee Labs have issued an alert that McAfee VirusScan DAT file 6329 is returning a false positive for spsgui.exe. This is impacting SAP telephone connectivity functionality.
McAfee have a work around for the issue documented in KB71739 https://kc.mcafee.com/corporate/index?page=content&id=KB71739
Chris Mohan --- Internet Storm Center Handler on Duty
They seem to be improving...at least it's not a core component of the OS this time :-)